Preheat your oven to 350°F. Line a 12-cupcake pan with liners.
In a small bowl, whisk together the cake flour, baking powder, baking soda, salt, and pumpkin pie spice.
In a large bowl, cream the softened butter and granulated sugar with an electric mixer on high speed until fluffy, about 2 minutes.
Add the egg and vanilla and mix on medium speed for 1-2 minutes until the mixture is pale and fluffy.
Mix in the canned pumpkin puree on low speed. Set aside.
Gradually add the dry ingredients and buttermilk to the wet ingredients, mixing until combined.
Fill each cupcake liner ¾ full using a large cookie scoop.
Bake for 17-19 minutes, until a toothpick inserted in the center comes out clean. Let the cupcakes cool in the pan for 10 minutes, then transfer them to a cooling rack to cool completely.