Spread salt on a shallow plate. Rub a lime wedge around the rim of a rocks glass, then dip the glass into the salt.
In the glass, muddle 2 to 3 strawberries with agave syrup. Add mezcal, Cointreau, and lime juice. Fill the glass with ice and stir well.
Garnish with a strawberry and lime wedge. Enjoy your refreshing strawberry mezcal margarita!